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"contents": "<span style=\"font-weight: 400;\">This week we learned that the Covid-19 vaccine developed by the University of Oxford and AstraZeneca appears to provide no measurable effect on mild or moderate disease caused by the variant of the virus first identified in South Africa, known as B.1.351.</span>\r\n\r\n<span style=\"font-weight: 400;\">This is </span><a href=\"https://www.wits.ac.za/covid19/covid19-news/latest/oxford-covid-19-vaccine-trial-results.html\"><span style=\"font-weight: 400;\">deeply disappointing news</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<p><img loading=\"lazy\" class=\"size-full wp-image-832571\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/MC-Covid-Suzman_1.jpg\" alt=\"\" width=\"1356\" height=\"668\" /> South Africa has temporarily halted the use of the AstraZeneca-Oxford University vaccine after evidence emerged that the vaccine did not protect clinical-trial participants from mild or moderate illness caused by the B.1.351 variant. (Photo: theconversation.com/Wikipedia)</p>\r\n\r\n<span style=\"font-weight: 400;\">People the world over are understandably frustrated and anxious as the pandemic continues to disrupt their lives. In South Africa, where many of my family members live, and in other countries where variants are spreading, people have been waiting for the promising science to translate into lives saved in their communities.</span>\r\n\r\n<span style=\"font-weight: 400;\">The whole world is grappling with a complicated and fluid situation. </span>\r\n\r\n<span style=\"font-weight: 400;\">We still don’t know, for example, if this vaccine could protect against severe or fatal disease caused by the variant, thereby preventing people from being hospitalised or needing supplemental oxygen, which is in short supply in some countries. </span>\r\n\r\n<span style=\"font-weight: 400;\">Additional information will be needed to answer these and other questions. The World Health Organisation and national health authorities will determine the potential public health value of this vaccine in South Africa and other countries, and make decisions about where and how it can be used.</span>\r\n\r\n<span style=\"font-weight: 400;\">While we may all be feeling destabilised now amid this swirl of questions, we must keep the big picture in mind. In science, every outcome is knowledge. </span>\r\n\r\n<span style=\"font-weight: 400;\">Without the researchers in South Africa who were able to quickly identify the variant and incorporate it into this clinical trial, the world would not yet know the effectiveness of the vaccine on this variant. </span>\r\n\r\n<span style=\"font-weight: 400;\">These world-class scientists have generated valuable new knowledge that will enable more targeted interventions, helping governments make important decisions about vaccine rollouts and better protect their people. </span>\r\n\r\n<span style=\"font-weight: 400;\">For example, a version of this vaccine is being rolled out in India, where B.1.351 hasn’t yet been detected. So while questions are being answered, this vaccine will continue to be a valuable tool in other parts of the world.</span>\r\n\r\n<span style=\"font-weight: 400;\">We’ve all been spoiled lately by how good the news on vaccine science has been. </span>\r\n\r\n<span style=\"font-weight: 400;\">The world went from seeing the emergence of a deadly new infectious disease to developing several safe and effective vaccines against it within the space of only 10 months – the fastest humans have ever gone from identifying a novel virus to inoculating against it. </span>\r\n\r\n<span style=\"font-weight: 400;\">Only four months ago, we weren’t sure any vaccine would work. </span>\r\n\r\n<span style=\"font-weight: 400;\">With several additional vaccines coming through the final phases of clinical trials, including those from </span><a href=\"https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial\"><span style=\"font-weight: 400;\">Johnson & Johnson</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3\"><span style=\"font-weight: 400;\">Novavax</span></a><span style=\"font-weight: 400;\">, we are still on a trajectory to get everyone protected against Covid-19. </span>\r\n\r\n<span style=\"font-weight: 400;\">It will take time for doses of those vaccines to become available, following regulatory approvals and manufacturing scale-up, but they will get out.</span>\r\n\r\n<span style=\"font-weight: 400;\">As a philanthropy, we will continue to do our part to keep up the momentum. Building on our longstanding partnerships, we are working with governments, multilateral organisations and private companies to determine how to respond to the latest data. </span>\r\n\r\n<p><img loading=\"lazy\" class=\"size-full wp-image-832597\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/MC-Covid-Suzman2.jpg\" alt=\"\" width=\"780\" height=\"501\" /> Mark Suzman, CEO of the Bill & Melinda Gates Foundation. (Photo: Supplied)</p>\r\n\r\n<span style=\"font-weight: 400;\">We will use </span><a href=\"https://ww2.gatesfoundation.org/ideas/articles/coronavirus-funding-additional-250-million-suzman\"><span style=\"font-weight: 400;\">our funding commitments of more than $1.75 billion</span></a><span style=\"font-weight: 400;\"> to help accelerate the development and distribution of vaccines that are optimized for lower- and middle-income countries and are effective against the variants. </span>\r\n\r\n<span style=\"font-weight: 400;\">We’ll also make new investments in treatments and diagnostics because we’ve learned that research and development on these important tools must accelerate as additional variants emerge.</span>\r\n\r\n<span style=\"font-weight: 400;\">Although the path forward is challenging, it is not bleak. </span>\r\n\r\n<span style=\"font-weight: 400;\">We have learned a great deal about what works to control this virus during 2020, and these lessons are increasingly being applied for an even more nimble and effective response in 2021.</span>\r\n\r\n<span style=\"font-weight: 400;\">A pandemic knows no borders. Leaving half the world without access to vaccines only means that more people will suffer and die, both at home and abroad. </span>\r\n\r\n<span style=\"font-weight: 400;\">As Bill and Melinda Gates </span><a href=\"https://www.gatesnotes.com/2021-Annual-Letter?WT.mc_id=20210127000000_AL2021_GFG-PGS_&WT.tsrc=GFGPGS&gclid=Cj0KCQiAvP6ABhCjARIsAH37rbRSwBVFxjN1AgowGFsB8oIGevPH8q1hexEFeny0yUvumyQE4evZZjQaAmLZEALw_wcB\"><span style=\"font-weight: 400;\">recently wrote in their annual letter</span></a><span style=\"font-weight: 400;\">, we are fighting against immunity inequality; an injustice that is bad on moral grounds, bad on economic grounds, and bad on public health grounds. </span>\r\n\r\n<span style=\"font-weight: 400;\">The world needs to reach vulnerable communities and healthcare workers with vaccines as quickly as possible, no matter where they live, if we’re going to get ahead of this virus.</span>\r\n\r\n<span style=\"font-weight: 400;\">To combat a global problem, global action is needed. </span>\r\n\r\n<span style=\"font-weight: 400;\">Many nations and organisations have worked to create, fund and promote collaborative international mechanisms to boost equitable access to Covid-19 vaccines. </span>\r\n\r\n<a href=\"https://www.who.int/initiatives/act-accelerator/covax\"><span style=\"font-weight: 400;\">Covax</span></a><span style=\"font-weight: 400;\"> remains far and away the biggest and most important multilateral initiative to tackle this challenge, but only if it urgently receives funding to support enough vaccines to outrace the virus. </span>\r\n\r\n<span style=\"font-weight: 400;\">Unfortunately, global manufacturing and procurement have remained underfunded while a bidding war for doses puts vaccines out of reach for the poorest countries. </span>\r\n\r\n<span style=\"font-weight: 400;\">Nations that understandably want to shore up their own health networks and vaccine delivery systems should also ramp up funding for Covax and reject the impulse to make bilateral deals that shut out other countries and delay the possibility of a global recovery.</span>\r\n\r\n<span style=\"font-weight: 400;\">If Covid-19 has taught the world anything over the past year, it is that we’re all in this together. Variants may continue to emerge that could put everyone at risk. </span>\r\n\r\n<span style=\"font-weight: 400;\">We cannot defeat this pandemic unless everyone, everywhere, has a chance to get vaccinated. </span><b>DM/MC</b>\r\n\r\n<i><span style=\"font-weight: 400;\">Mark Suzman is the CEO of the Bill & Melinda Gates Foundation.</span></i>\r\n\r\n<i><span style=\"font-weight: 400;\">Information pertaining to Covid-19, vaccines, how to control the spread of the virus and potential treatments is ever-changing. Under the South African Disaster Management Act Regulation 11(5)(c), it is prohibited to publish information through any medium with the intention to deceive people on government measures to address Covid-19. We are, therefore, disabling the comment section on this article in order to protect both the commenting member and ourselves from potential liability. Should you have additional information we should know about, please email </span></i><i><span style=\"font-weight: 400;\">[email protected]</span></i>",
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"description": "<span style=\"font-weight: 400;\">This week we learned that the Covid-19 vaccine developed by the University of Oxford and AstraZeneca appears to provide no measurable effect on mild or moderate disease caused by the variant of the virus first identified in South Africa, known as B.1.351.</span>\r\n\r\n<span style=\"font-weight: 400;\">This is </span><a href=\"https://www.wits.ac.za/covid19/covid19-news/latest/oxford-covid-19-vaccine-trial-results.html\"><span style=\"font-weight: 400;\">deeply disappointing news</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n[caption id=\"attachment_832571\" align=\"aligncenter\" width=\"1356\"]<img class=\"size-full wp-image-832571\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/MC-Covid-Suzman_1.jpg\" alt=\"\" width=\"1356\" height=\"668\" /> South Africa has temporarily halted the use of the AstraZeneca-Oxford University vaccine after evidence emerged that the vaccine did not protect clinical-trial participants from mild or moderate illness caused by the B.1.351 variant. (Photo: theconversation.com/Wikipedia)[/caption]\r\n\r\n<span style=\"font-weight: 400;\">People the world over are understandably frustrated and anxious as the pandemic continues to disrupt their lives. In South Africa, where many of my family members live, and in other countries where variants are spreading, people have been waiting for the promising science to translate into lives saved in their communities.</span>\r\n\r\n<span style=\"font-weight: 400;\">The whole world is grappling with a complicated and fluid situation. </span>\r\n\r\n<span style=\"font-weight: 400;\">We still don’t know, for example, if this vaccine could protect against severe or fatal disease caused by the variant, thereby preventing people from being hospitalised or needing supplemental oxygen, which is in short supply in some countries. </span>\r\n\r\n<span style=\"font-weight: 400;\">Additional information will be needed to answer these and other questions. The World Health Organisation and national health authorities will determine the potential public health value of this vaccine in South Africa and other countries, and make decisions about where and how it can be used.</span>\r\n\r\n<span style=\"font-weight: 400;\">While we may all be feeling destabilised now amid this swirl of questions, we must keep the big picture in mind. In science, every outcome is knowledge. </span>\r\n\r\n<span style=\"font-weight: 400;\">Without the researchers in South Africa who were able to quickly identify the variant and incorporate it into this clinical trial, the world would not yet know the effectiveness of the vaccine on this variant. </span>\r\n\r\n<span style=\"font-weight: 400;\">These world-class scientists have generated valuable new knowledge that will enable more targeted interventions, helping governments make important decisions about vaccine rollouts and better protect their people. </span>\r\n\r\n<span style=\"font-weight: 400;\">For example, a version of this vaccine is being rolled out in India, where B.1.351 hasn’t yet been detected. So while questions are being answered, this vaccine will continue to be a valuable tool in other parts of the world.</span>\r\n\r\n<span style=\"font-weight: 400;\">We’ve all been spoiled lately by how good the news on vaccine science has been. </span>\r\n\r\n<span style=\"font-weight: 400;\">The world went from seeing the emergence of a deadly new infectious disease to developing several safe and effective vaccines against it within the space of only 10 months – the fastest humans have ever gone from identifying a novel virus to inoculating against it. </span>\r\n\r\n<span style=\"font-weight: 400;\">Only four months ago, we weren’t sure any vaccine would work. </span>\r\n\r\n<span style=\"font-weight: 400;\">With several additional vaccines coming through the final phases of clinical trials, including those from </span><a href=\"https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial\"><span style=\"font-weight: 400;\">Johnson & Johnson</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3\"><span style=\"font-weight: 400;\">Novavax</span></a><span style=\"font-weight: 400;\">, we are still on a trajectory to get everyone protected against Covid-19. </span>\r\n\r\n<span style=\"font-weight: 400;\">It will take time for doses of those vaccines to become available, following regulatory approvals and manufacturing scale-up, but they will get out.</span>\r\n\r\n<span style=\"font-weight: 400;\">As a philanthropy, we will continue to do our part to keep up the momentum. Building on our longstanding partnerships, we are working with governments, multilateral organisations and private companies to determine how to respond to the latest data. </span>\r\n\r\n[caption id=\"attachment_832597\" align=\"aligncenter\" width=\"780\"]<img class=\"size-full wp-image-832597\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/MC-Covid-Suzman2.jpg\" alt=\"\" width=\"780\" height=\"501\" /> Mark Suzman, CEO of the Bill & Melinda Gates Foundation. (Photo: Supplied)[/caption]\r\n\r\n<span style=\"font-weight: 400;\">We will use </span><a href=\"https://ww2.gatesfoundation.org/ideas/articles/coronavirus-funding-additional-250-million-suzman\"><span style=\"font-weight: 400;\">our funding commitments of more than $1.75 billion</span></a><span style=\"font-weight: 400;\"> to help accelerate the development and distribution of vaccines that are optimized for lower- and middle-income countries and are effective against the variants. </span>\r\n\r\n<span style=\"font-weight: 400;\">We’ll also make new investments in treatments and diagnostics because we’ve learned that research and development on these important tools must accelerate as additional variants emerge.</span>\r\n\r\n<span style=\"font-weight: 400;\">Although the path forward is challenging, it is not bleak. </span>\r\n\r\n<span style=\"font-weight: 400;\">We have learned a great deal about what works to control this virus during 2020, and these lessons are increasingly being applied for an even more nimble and effective response in 2021.</span>\r\n\r\n<span style=\"font-weight: 400;\">A pandemic knows no borders. Leaving half the world without access to vaccines only means that more people will suffer and die, both at home and abroad. </span>\r\n\r\n<span style=\"font-weight: 400;\">As Bill and Melinda Gates </span><a href=\"https://www.gatesnotes.com/2021-Annual-Letter?WT.mc_id=20210127000000_AL2021_GFG-PGS_&WT.tsrc=GFGPGS&gclid=Cj0KCQiAvP6ABhCjARIsAH37rbRSwBVFxjN1AgowGFsB8oIGevPH8q1hexEFeny0yUvumyQE4evZZjQaAmLZEALw_wcB\"><span style=\"font-weight: 400;\">recently wrote in their annual letter</span></a><span style=\"font-weight: 400;\">, we are fighting against immunity inequality; an injustice that is bad on moral grounds, bad on economic grounds, and bad on public health grounds. </span>\r\n\r\n<span style=\"font-weight: 400;\">The world needs to reach vulnerable communities and healthcare workers with vaccines as quickly as possible, no matter where they live, if we’re going to get ahead of this virus.</span>\r\n\r\n<span style=\"font-weight: 400;\">To combat a global problem, global action is needed. </span>\r\n\r\n<span style=\"font-weight: 400;\">Many nations and organisations have worked to create, fund and promote collaborative international mechanisms to boost equitable access to Covid-19 vaccines. </span>\r\n\r\n<a href=\"https://www.who.int/initiatives/act-accelerator/covax\"><span style=\"font-weight: 400;\">Covax</span></a><span style=\"font-weight: 400;\"> remains far and away the biggest and most important multilateral initiative to tackle this challenge, but only if it urgently receives funding to support enough vaccines to outrace the virus. </span>\r\n\r\n<span style=\"font-weight: 400;\">Unfortunately, global manufacturing and procurement have remained underfunded while a bidding war for doses puts vaccines out of reach for the poorest countries. </span>\r\n\r\n<span style=\"font-weight: 400;\">Nations that understandably want to shore up their own health networks and vaccine delivery systems should also ramp up funding for Covax and reject the impulse to make bilateral deals that shut out other countries and delay the possibility of a global recovery.</span>\r\n\r\n<span style=\"font-weight: 400;\">If Covid-19 has taught the world anything over the past year, it is that we’re all in this together. Variants may continue to emerge that could put everyone at risk. </span>\r\n\r\n<span style=\"font-weight: 400;\">We cannot defeat this pandemic unless everyone, everywhere, has a chance to get vaccinated. </span><b>DM/MC</b>\r\n\r\n<i><span style=\"font-weight: 400;\">Mark Suzman is the CEO of the Bill & Melinda Gates Foundation.</span></i>\r\n\r\n<i><span style=\"font-weight: 400;\">Information pertaining to Covid-19, vaccines, how to control the spread of the virus and potential treatments is ever-changing. Under the South African Disaster Management Act Regulation 11(5)(c), it is prohibited to publish information through any medium with the intention to deceive people on government measures to address Covid-19. We are, therefore, disabling the comment section on this article in order to protect both the commenting member and ourselves from potential liability. Should you have additional information we should know about, please email </span></i><i><span style=\"font-weight: 400;\">[email protected]</span></i>",
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