Medical misinformation: South African experts condemn ‘abortion pill reversal’ treatment

“If you go to a pharmacy and you can get them to call me […] I will prescribe [it] telephonically,” a South African doctor emailed our undercover reporter, who was posing as a pregnant woman who had changed her mind about having an abortion. 

The doctor was referring to “abortion pill reversal” (APR), a controversial treatment that claims to “reverse” a medical abortion (which consists of two pills taken a few days apart and can end pregnancies at up to 10 weeks). 

An online hotline – run from the US by Heartbeat International, a conservative Christian group that opposes abortion – connects women to doctors around the world who will prescribe APR. 

Last year, openDemocracy revealed that this group has affiliates globally that run “crisis pregnancy centres” providing women with misinformation about healthcare, including false claims that abortion “causes cancer”.  

Our reporter was first connected to a US activist who emailed her a “consent form” produced by Heartbeat. She was then connected to Doctors for Life, a  South African anti-abortion group, that gave her contacts of two local doctors – including the one who offered to prescribe this “treatment” without either meeting or speaking to her. 

“There is no evidence to support that it works and telling women that it does is misleading and wrong,” Dr Margit Endler told openDemocracy about APR. 

An obstetrician and gynaecologist, Endler is a specialist in postpartum haemorrhage and abortion, as well as a senior lecturer at the University of Cape Town’s Women’s Health Research Unit and an obstetric consultant at Söder Hospital in Stockholm.

“Abortion pill reversal” procedures were first developed by a controversial California-based family physician, who is now a Heartbeat medical adviser. Its proponents claim that high doses of progesterone, taken after mifepristone, the first pill prescribed for medical abortion, can “reverse” the abortion. 

A US trial to test the effectiveness and safety of APR was halted in 2019 after some participants were hospitalised with severe haemorrhaging.

openDemocracy discovered that doctors on four continents – Africa, Europe, South America and North America – are offering women this “treatment”. 

In the UK, a doctor told our undercover reporter that “about 100 women” in that country had already taken the “treatment”. In other places, the use of “abortion pill reversal” seems new and it’s unclear how many women have been involved. None of these countries’ medical authorities recognise APR.

South African health experts explained that it is unproven – and unlikely – that taking high doses of progesterone is effective in stopping a medical abortion. 

If the abortion does not happen, it is probably because the woman hasn’t taken the second abortion pill. If the second pill (misoprostol) is not taken within 24-48 hours of the first pill (mifepristone), an abortion will happen in only 8-46% of cases, according to a systematic review. 

“I think the reason anti-abortion activists find support that progesterone reverses the abortion is because mifepristone would not have ended the pregnancy in the first place,” said Endler. 

“The scant data that exists on mifepristone ‘reversal’ is based on case series and is of unsubstantial size to address this question,” she added.

Dr Judy Kluge, a consultant obstetrician and gynaecologist at the University of Stellenbosch who specialises in family planning, agreed with Endler: “Although the abortion pill reversal site claimed that progesterone was effective in 64-68% of cases, how does this compare to the abortion rate of women who just drink mifepristone?”

Kluge’s main concern was the “long-term effects on the foetus with the use of mifepristone” if such a pregnancy continued.

As progesterone has been used in pregnancies to prevent pre-term birth, Kluge said she was “not so concerned about the natural progesterone’s effect as much as preventing an abortion after the use of a drug [mifepristone] for which the long-term effect is not known”.

(Photo: pregnancycentereast.com / Wikipedia)