One in four South Africans with HIV not on treatment – new estimates

4 Apr 2024

Despite South Africa’s impressive HIV testing figures, a subset of people start taking antiretroviral therapy far later than is ideal for their health. This is according to new data from the leading mathematical model of HIV in the country.

About 50,000 people died of HIV-related causes and around 7.8 million were living with HIV in South Africa in 2023. This is according to new estimates from Thembisa, the leading mathematical model of HIV in South Africa.

The new figures were particularly keenly anticipated since they factor in numbers from both Statistics South Africa’s Census 2022 and the Human Sciences Research Council’s Sixth South African National HIV Prevalence, Incidence and Behaviour survey.

Of the estimated 7.8 million people living with HIV in South Africa in 2023 (12.6% of the population), just under 5.9 million were on treatment.

This translates to treatment coverage of 75%, or one in every four people living with HIV not being on treatment. Antiretroviral treatment is recommended for all people living with the infection.

The new Thembisa outputs for the first time include an estimate of people disengaging with treatment. It is calculated that an estimated one million people living with HIV who have previously taken antiretroviral treatment were not taking the treatment in mid-2023.

Of the roughly two million people living with HIV who are not on treatment, half were previously on treatment.

This suggests that helping and supporting people to start and stay on HIV treatment should be a high priority for the Department of Health.

Around 237,000 people started taking antiretroviral therapy in 2023 in South Africa.

Concerningly, over 46,000 adults started taking treatment only once their CD4 counts had dropped below 200 cells per cubic millimetre of blood.

A CD4 count of less than 200 indicates a compromised immune system and is associated with a higher risk of falling ill with co-infections such as tuberculosis.

These numbers suggest that, despite South Africa’s impressive HIV testing figures, there is a subset of people who are falling through the cracks and who only start taking treatment far later than is ideal for their health.

New infections declining

There were around 149,000 new HIV infections in South Africa in 2023, according to the new Thembisa estimates.

Here, as in most areas, the long term trend is downward, with new infections having been above 500,000 per year around the turn of the century and declining ever since.

As with other indicators, the sex differences are stark.

There were around 91,000 new HIV infections in women aged 15 and older, compared to 50,000 in men in the same age group.

hiv treatment

Since the number of new HIV infections is still higher than the total number of deaths in people living with HIV (as shown in the above graph), the absolute number of people living with HIV in South Africa is still rising and is anticipated to keep rising for some years to come.

One indicator that the HIV response in South Africa is generally heading in the right direction is that the number of people starting HIV treatment is significantly higher than the number of new infections.

The ratio between these two numbers was estimated at 1.6 in 2023 – in other words, for every 10 people newly infected, 16 were started on treatment. A decade ago, this ratio was often above 2.

95-95-95 indicators

According to UNAids, countries should aim for 95% of people living with HIV to be diagnosed, 95% of those diagnosed should be on treatment, and 95% of those on treatment should have viral suppression, all by 2025.

South Africa is on track to meet the first of these three targets with an estimated 95.4% of people living with HIV in 2023 having been diagnosed.

On the second target, performance is much weaker.

An estimated 78.7% of people who have been diagnosed with HIV were on treatment in 2023. In other words, more than one in five people who know they are living with HIV are not taking treatment. (Note: If you expand the definition of the second 95 target to include both diagnosed and undiagnosed people, then you get the 75% treatment coverage figure quoted near the top of this article.)

On the third target, South Africa is doing well, with an estimated 91.3% of people who are on HIV treatment being virally suppressed.

However, if one throws the net wider and asks what percentage of all people living with HIV – not just those on treatment – are virally suppressed, the number plummets to 68.6%. (These figures are for a viral load threshold of 1,000 copies per millilitre of blood. If a threshold of 400 is used, the estimates are 89% and 66.8% respectively.)

Life expectancy

The latest Thembisa figures also indicate that life expectancy in South Africa has continued its upward trend following a blip in 2020 and 2021 caused by the Covid pandemic.

hiv treatment

The broader picture of the last 30 years shows a clear decline caused by the HIV pandemic, reaching a low point of 53.6 in 2004, followed by a steady recovery as antiretroviral treatment became available and fewer people died of HIV.

Life expectancy in 2023 was estimated at 65.9 – 62.3 for males and 69.7 for females.

Note: This article is based on outputs from Thembisa version 4.7 which was published at the end of March 2024. Spotlight will soon publish more articles and visualisations unpacking these outputs in more detail. Graphs in this article were made using the R package ggplot2. DM

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South Africa

New infections declining

95-95-95 indicators

Life expectancy