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"title": "Free home tests for sexually transmitted infections could be coming to South Africa",
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"contents": "<span style=\"font-weight: 400;\">Free home tests for four common – and curable – sexually transmitted infections (STIs) – </span><a href=\"https://www.mayoclinic.org/diseases-conditions/gonorrhea/symptoms-causes/syc-20351774\"><span style=\"font-weight: 400;\">gonorrhoea</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.mayoclinic.org/diseases-conditions/chlamydia/symptoms-causes/syc-20355349\"><span style=\"font-weight: 400;\">chlamydia</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.mayoclinic.org/diseases-conditions/syphilis/symptoms-causes/syc-20351756#:~:text=Syphilis%20is%20a%20bacterial%20infection,membrane%20contact%20with%20these%20sores.\"><span style=\"font-weight: 400;\">syphilis</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://www.mayoclinic.org/diseases-conditions/trichomoniasis/symptoms-causes/syc-20378609#:~:text=Trichomoniasis%20is%20a%20common%20sexually,trichomoniasis%20typically%20have%20no%20symptoms.\"><span style=\"font-weight: 400;\">trichomoniasis</span></a><span style=\"font-weight: 400;\"> – could soon be available at </span><a href=\"https://getcheckedgocollect.org.za/ccmdd/\"><span style=\"font-weight: 400;\">chronic medicine pick-up points</span></a><span style=\"font-weight: 400;\"> around the country, according to a draft of South Africa’s fifth </span><a href=\"https://nsp.sanac.org.za/uploads/files/NSPn-for-HIV-TB-STIs-2023-2028-Draft3C.pdf\"><span style=\"font-weight: 400;\">HIV, TB and STI action plan</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">Government clinics will also roll out STI tests that give results on the same day. </span>\r\n\r\n<span style=\"font-weight: 400;\">The new plan is being finalised after comments from the public and civil society were added, says Nelson Dlamini, communications manager at the South African National Aids Council. The final draft will be published on </span><a href=\"https://www.who.int/campaigns/world-tb-day\"><span style=\"font-weight: 400;\">World TB Day</span></a><span style=\"font-weight: 400;\"> on 24 March.</span>\r\n\r\n<span style=\"font-weight: 400;\">The updated strategy will run from 2023 to 2028. </span>\r\n\r\n<span style=\"font-weight: 400;\">Until now, South Africa’s public health sector hasn’t used tests as a standard to diagnose these four STIs (apart from </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">syphilis</span></a><span style=\"font-weight: 400;\">). Instead, people get treated only if they show up to a facility with symptoms such as </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">genital sores</span></a><span style=\"font-weight: 400;\"> or </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">discharge</span></a><span style=\"font-weight: 400;\"> coming from their penis or vagina. </span>\r\n\r\n<span style=\"font-weight: 400;\">This is called “</span><a href=\"https://sahivsoc.org/Files/SAHCS%202022%20STI%20guidelines.pdf\"><span style=\"font-weight: 400;\">syndromic management</span></a><span style=\"font-weight: 400;\">” and it’s used by </span><a href=\"https://www.who.int/publications/i/item/9789240024168\"><span style=\"font-weight: 400;\">many low- and middle-income countries</span></a><span style=\"font-weight: 400;\">, including </span><a href=\"https://www.jica.go.jp/project/tanzania/001/materials/pdf/sti_01.pdf\"><span style=\"font-weight: 400;\">Tanzania</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05276-0\"><span style=\"font-weight: 400;\">Mozambique</span></a><span style=\"font-weight: 400;\">. The </span><a href=\"https://sahivsoc.org/Files/SAHCS%202022%20STI%20guidelines.pdf\"><span style=\"font-weight: 400;\">logic</span></a><span style=\"font-weight: 400;\"> is that many facilities don’t have easy access to a laboratory, so it might take up to </span><a href=\"https://www.sciencedirect.com/science/article/pii/S0732889316303467\"><span style=\"font-weight: 400;\">four days</span></a><span style=\"font-weight: 400;\"> for people to get their results, and then they might not return to the clinic to get the news or the medicine anyway. </span>\r\n\r\n<span style=\"font-weight: 400;\">In South Africa’s private sector, however, using lab tests to diagnose STIs is commonplace. </span>\r\n\r\n<span style=\"font-weight: 400;\">The trouble with the syndromic method is twofold: </span>\r\n\r\n<span style=\"font-weight: 400;\">First, </span><a href=\"https://www.sciencedirect.com/science/article/pii/S0091743502000580\"><span style=\"font-weight: 400;\">most people</span></a><span style=\"font-weight: 400;\"> with these STIs are asymptomatic, meaning they don’t show any symptoms (that was the case for more than three-quarters of women in </span><a href=\"https://academic.oup.com/jid/article/206/1/6/833481\"><span style=\"font-weight: 400;\">one local study</span></a><span style=\"font-weight: 400;\">). So, with the current approach in the public health system, it means they won’t be treated and will continue to spread the infection to others.</span>\r\n\r\n<span style=\"font-weight: 400;\">What’s more, the Health Department doesn’t consistently collect data on how many people have one of the four common STIs (gonorrhoea, chlamydia, syphilis and trichomoniasis) on a national level. Instead, the department and the National Institute for Communicable Diseases </span><a href=\"https://www.nicd.ac.za/wp-content/uploads/2017/03/3Final-25-April-2017_Revised-NAS_v5_NICD.pdf\"><span style=\"font-weight: 400;\">run data collection drives every now and again</span></a><span style=\"font-weight: 400;\">, where samples are collected from people (who are showing symptoms) in all nine provinces and sent to the lab. The results are used to make predictions about how many of these infections are going around, and the department then decides whether it’s buying the correct medicines. </span>\r\n\r\n<i><span style=\"font-weight: 400;\">Read in </span></i><span style=\"font-weight: 400;\">Daily Maverick:</span><i><span style=\"font-weight: 400;\"> “</span></i><a href=\"https://www.dailymaverick.co.za/article/2022-08-11-one-pill-within-three-days-of-condomless-sex-could-stop-three-sexually-transmitted-infections/\"><i><span style=\"font-weight: 400;\">One pill within three days of condomless sex could stop three sexually transmitted infections</span></i></a><i><span style=\"font-weight: 400;\">”</span></i>\r\n\r\n<span style=\"font-weight: 400;\">This type of data collection makes it difficult to know whether the country reached the government’s </span><a href=\"https://bhekisisa.org/wp-content/uploads/2023/02/NSP-MTR-Full-Report-2017-2022-FINAL.pdf\"><span style=\"font-weight: 400;\">previous HIV and STI plan’s</span></a><span style=\"font-weight: 400;\"> (2017-22) goal to find </span><a href=\"https://bhekisisa.org/wp-content/uploads/2023/02/NSP-MTR-Full-Report-2017-2022-FINAL.pdf\"><span style=\"font-weight: 400;\">50%</span></a><span style=\"font-weight: 400;\"> more symptomless cases of these four infections by the end of 2022, says Yogan Pillay, who heads the </span><a href=\"https://www.clintonhealthaccess.org/south-africa/\"><span style=\"font-weight: 400;\">local arm of the Clinton Health Access Initiative</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">When gonorrhoea, syphilis or chlamydia aren’t treated, they can </span><a href=\"https://www.tandfonline.com/doi/pdf/10.1016/S0968-8080(12)40653-X\"><span style=\"font-weight: 400;\">cause infertility</span></a><span style=\"font-weight: 400;\">, increase the chance of </span><a href=\"https://www.who.int/news-room/fact-sheets/detail/sexually-transmitted-infections-(stis)\"><span style=\"font-weight: 400;\">contracting HIV</span></a><span style=\"font-weight: 400;\"> or lead to </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525108/\"><span style=\"font-weight: 400;\">stillbirth</span></a><span style=\"font-weight: 400;\">. People with HIV who aren’t on antiretroviral treatment can also </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715951/\"><span style=\"font-weight: 400;\">spread the virus easier</span></a><span style=\"font-weight: 400;\"> when they have gonorrhoea.</span><span style=\"font-weight: 400;\"> </span>\r\n\r\n<span style=\"font-weight: 400;\">The second problem is that people who do have symptoms (and who show up to a clinic for help) will get an antibiotic that works against more than one infection, because health workers don’t know exactly what they’re treating. This could result in some bugs becoming resistant to those medicines, </span><a href=\"https://bhekisisa.org/article/2022-07-22-superbugs-could-cost-you-an-arm-or-a-leg-why-hospitals-need-more-money-to-fight-drug-resistance/\"><span style=\"font-weight: 400;\">something South Africa already struggles with</span></a><i><span style=\"font-weight: 400;\">.</span></i>\r\n\r\n<span style=\"font-weight: 400;\">In short: the public health system is potentially overtreating people with symptoms and undertreating those without, explains Johan Hugo, a senior clinical adviser at the </span><a href=\"https://www.anovahealth.co.za\"><span style=\"font-weight: 400;\">Anova Health Institute</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">But the way South Africa approaches both these problems – through diagnostics and data – is changing. Here’s how. </span>\r\n<h4>Diagnostics: finding the patients</h4>\r\n<span style=\"font-weight: 400;\">Testing people, such as pregnant women, when they come to clinics could make a big difference, according to </span><a href=\"https://www.hindawi.com/journals/idog/2018/3946862/\"><span style=\"font-weight: 400;\">research</span></a><span style=\"font-weight: 400;\"> published in the journal </span><i><span style=\"font-weight: 400;\">Infectious Diseases in Obstetrics and Gynaecology </span></i><span style=\"font-weight: 400;\">in 2018</span><i><span style=\"font-weight: 400;\">. </span></i>\r\n\r\n<span style=\"font-weight: 400;\">At three clinics in Tshwane, pregnant women used rapid tests for gonorrhoea, chlamydia and trichomoniasis. Nine out of 10 of those who tested positive for any of these infections could start treatment immediately, without having to wait longer for help than they would have been in the queue.</span>\r\n\r\n<span style=\"font-weight: 400;\">However, these tests are </span><a href=\"https://journals.co.za/doi/10.36303/SAGP.2022.3.3.0132\"><span style=\"font-weight: 400;\">not widely available</span></a><span style=\"font-weight: 400;\"> in South Africa’s public sector. State facilities have rapid tests for syphilis, which are </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">commonly given to pregnant women and survivors of sexual violence</span></a><span style=\"font-weight: 400;\">, but are not available as a standard or for the three other STIs. </span>\r\n\r\n<span style=\"font-weight: 400;\">Under the new STI plan, though, tests would be available to many more people, including all teenage girls and young women (between 15 and 24 years old), </span><a href=\"https://www.cdc.gov/hiv/group/sexworkers.html\"><span style=\"font-weight: 400;\">sex workers</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.cdc.gov/std/treatment-guidelines/trans.htm\"><span style=\"font-weight: 400;\">transgender people</span></a><span style=\"font-weight: 400;\">, men who have sex with men and survivors of gender-based violence. </span>\r\n\r\n<span style=\"font-weight: 400;\">In the private sector, </span><a href=\"https://famka.co.za/product-category/test-kit/\"><span style=\"font-weight: 400;\">rapid self-test kits for single STIs cost between R125 and R200 </span></a><span style=\"font-weight: 400;\">or </span><a href=\"https://famka.co.za/product/std-combo-kit/\"><span style=\"font-weight: 400;\">R500</span></a><span style=\"font-weight: 400;\"> for a kit that will screen for all four curable STIs.</span>\r\n\r\n<span style=\"font-weight: 400;\">Another option for the state could be to use the GeneXpert machines, already available for testing for TB, to pick up whether someone has a chlamydia and gonorrhoea infection, says Hugo. </span>\r\n\r\n<span style=\"font-weight: 400;\">With this machine, test results are available within </span><a href=\"https://www.frontiersin.org/articles/10.3389/fcimb.2021.784610/full#:~:text=On%20the%20other%20hand%2C%20the,amplification%20in%20approximately%2090%20min.\"><span style=\"font-weight: 400;\">90 minutes</span></a><span style=\"font-weight: 400;\"> when using the chlamydia and gonorrhoea cartridges. All health workers have to do is replace the TB or HIV test kit inside the machine with one that works for a specific STI. </span>\r\n\r\n<span style=\"font-weight: 400;\">When </span><a href=\"https://sti.bmj.com/content/sextrans/early/2018/05/10/sextrans-2017-053443.full.pdf\"><span style=\"font-weight: 400;\">researchers tested this method</span></a><span style=\"font-weight: 400;\"> in 12 clinics in Australia, it worked just as well as laboratory tests, </span><a href=\"https://sti.bmj.com/content/sextrans/early/2018/05/10/sextrans-2017-053443.full.pdf\"><span style=\"font-weight: 400;\">research shows</span></a><span style=\"font-weight: 400;\"> — and it’s much faster.</span>\r\n\r\n<span style=\"font-weight: 400;\">A </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918163/\"><span style=\"font-weight: 400;\">study</span></a><span style=\"font-weight: 400;\"> from Durban that used the GeneXpert machine to test for STIs gave similar results, and women who tested positive received medication and a pack of information, condoms and treatment for their sexual partners as soon as the results were out. The patients told researchers that this method worked for them because they got results quickly (within about two hours) and because they could help their partners.</span>\r\n\r\n<i><span style=\"font-weight: 400;\">Read in </span></i><span style=\"font-weight: 400;\">Daily Maverick:</span><i><span style=\"font-weight: 400;\"> “</span></i><a href=\"https://www.dailymaverick.co.za/article/2023-02-13-conversations-about-sex-we-must-do-better-for-young-people/\"><i><span style=\"font-weight: 400;\">Conversations about sex – we must do better for young people</span></i></a><i><span style=\"font-weight: 400;\">”</span></i>\r\n\r\n<span style=\"font-weight: 400;\">The cartridges are pricey, though – it could cost </span><a href=\"https://sti.bmj.com/content/sextrans/93/Suppl_2/A211.1.full.pdf\"><span style=\"font-weight: 400;\">about R250</span></a><span style=\"font-weight: 400;\"> a shot to test for gonorrhoea. So, although the Durban study showed that this method could be good for diagnosing STIs fast, it didn’t look at whether it would be an affordable option for South Africa. </span>\r\n\r\n<span style=\"font-weight: 400;\">But if people can get their STI results so fast in clinics, why would the government also roll out home tests?</span>\r\n\r\n<hr />\r\n\r\n<strong>Visit <a href=\"https://www.dailymaverick.co.za?utm_source=direct&utm_medium=in_article_link&utm_campaign=homepage\"><em>Daily Maverick's</em> home page</a> for more news, analysis and investigations</strong>\r\n\r\n<hr />\r\n\r\n<span style=\"font-weight: 400;\">It’s a way to get around stigma, the action plan says. Discrimination at clinics makes it hard for people to get the health services they need – especially people who are at a high risk of contracting STIs, such as </span><a href=\"https://www.cdc.gov/hiv/group/sexworkers.html\"><span style=\"font-weight: 400;\">sex workers</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://www.cdc.gov/std/treatment-guidelines/trans.htm\"><span style=\"font-weight: 400;\">transgender people</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">Close to 40% of the practitioners involved in </span><a href=\"https://sti.bmj.com/content/84/2/150.short\"><span style=\"font-weight: 400;\">one study</span></a><span style=\"font-weight: 400;\"> felt uncomfortable caring for patients who come from such high-risk groups, also called key populations.</span>\r\n\r\n<span style=\"font-weight: 400;\">In a Brazilian study, transgender women said they were far </span><a href=\"https://www.sciencedirect.com/science/article/pii/S1413867022000447\"><span style=\"font-weight: 400;\">more comfortable collecting their own samples</span></a><span style=\"font-weight: 400;\"> (from their anus, urethra or mouth) than having a health worker do it. </span>\r\n\r\n<p><img loading=\"lazy\" class=\"size-full wp-image-1565054\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/2023/02/MC-STI-2-1.jpg\" alt=\"\" width=\"720\" height=\"360\" /> A rapid screening test for syphilis. (Photo: iStock)</p>\r\n\r\n<span style=\"font-weight: 400;\">Pillay cautions, though, that sending out self-test kits could create another set of problems when it comes to keeping track of infections. </span>\r\n\r\n<span style=\"font-weight: 400;\">Health workers wouldn’t know whether people used the test, he says, and if they have, there’s no guarantee they would come in for treatment. </span>\r\n<h4>Data: Getting the numbers</h4>\r\n<span style=\"font-weight: 400;\">There were more than 4.5 million estimated new cases of gonorrhoea in South Africa in 2017, as well as 5.8 million new chlamydia infections and 70,000 cases of syphilis, </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188893/\"><span style=\"font-weight: 400;\">according to a 2018 modelling study</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">But these figures are only educated guesses and could be inflated, the researchers caution, because there wasn’t much data for them to work with. That meant they had to do “crude” calculations based on figures from a bunch of smaller studies, which didn’t all have the same research method. </span>\r\n\r\n<span style=\"font-weight: 400;\">Under the new HIV and STI plan, the Health Department says it will conduct nationally representative studies to determine how many of these STIs are going around among the people most likely to be infected (such as sex workers and young women). </span>\r\n\r\n<span style=\"font-weight: 400;\">This data will make it easier for South Africa to find and treat more people with STIs, without having to test everyone in the country, Pillay says. </span>\r\n\r\n<span style=\"font-weight: 400;\">In the meantime, health facilities are going to change the way they collect data for people who are showing symptoms of STIs. </span>\r\n\r\n<span style=\"font-weight: 400;\">At the moment, health workers only record information for </span><a href=\"https://emedicine.medscape.com/article/778374-overview\"><span style=\"font-weight: 400;\">male urethritis syndrome</span></a><span style=\"font-weight: 400;\">. This is a condition where a bacterial infection – which is sexually transmitted – causes inflammation in the urethra (the tube along which urine flows out from the bladder). Close to </span><a href=\"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205863#pone.0205863.s002\"><span style=\"font-weight: 400;\">311,000 men showed up at healthcare facilities with symptoms of this condition</span></a><span style=\"font-weight: 400;\"> in 2017. </span>\r\n\r\n<span style=\"font-weight: 400;\">While </span><a href=\"https://www.cdc.gov/std/health-disparities/stds-women-042011.pdf\"><span style=\"font-weight: 400;\">men are more likely than women to show symptoms</span></a><span style=\"font-weight: 400;\"> of infections such as chlamydia and gonorrhoea, they’re much less likely to ask for help quickly, Pillay notes. </span>\r\n\r\n<span style=\"font-weight: 400;\">But in the next few months, health workers are likely to start recording cases of </span><a href=\"https://www.ampath.co.za/storage/347/ampathchat_66-vaginal-discharge-syndrome-17022020-final.pdf\"><span style=\"font-weight: 400;\">vaginal discharge syndrome</span></a><span style=\"font-weight: 400;\"> in women and </span><a href=\"https://clinicalinfo.hiv.gov/en/glossary/genital-ulcer-disease\"><span style=\"font-weight: 400;\">genital ulcer disease</span></a><span style=\"font-weight: 400;\"> too, he says, because these are underlying symptoms of STIs like chlamydia and </span><a href=\"https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus\"><span style=\"font-weight: 400;\">herpes</span></a><span style=\"font-weight: 400;\"> among this gender. </span>\r\n\r\n<span style=\"font-weight: 400;\">Tracking these two syndromes can help the government to understand STI trends in women who show symptoms, so that it can pick up in which areas more intensive testing and treatment has to happen, explains Pillay.</span>\r\n\r\n<span style=\"font-weight: 400;\">To help make sure the people who need treatment get it, the department also plans to add an STI section to the country’s tracking platform, </span><a href=\"https://www.tier.net/\"><span style=\"font-weight: 400;\">Tier.Net</span></a><span style=\"font-weight: 400;\">, that helps monitor people who are on HIV and TB treatment. </span>\r\n\r\n<span style=\"font-weight: 400;\">This system keeps track of people who are on HIV medication, for example, so that health workers know to test their viral load (how much of the virus is in their blood) each time the patient arrives for a check-up at the clinic. The online platform doubles as a way to</span><a href=\"https://sahivsoc.org/Files/transition.pdf\"><span style=\"font-weight: 400;\"> collect data and filter it to the government</span></a><span style=\"font-weight: 400;\"> to help manage the country’s response to HIV infections. In the same way it could help to also keep track of STI numbers. </span>\r\n\r\n<span style=\"font-weight: 400;\">But Tier.Net has had drawbacks, research shows. Health workers have battled to keep it updated alongside the paper records, which has </span><a href=\"https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000312\"><span style=\"font-weight: 400;\">resulted in mismatches</span></a><span style=\"font-weight: 400;\"> between what’s on electronic sheets and what’s in a clinic’s books.</span>\r\n\r\n<span style=\"font-weight: 400;\">Until then, Pillay says, health workers should simply encourage more people to get screened for STIs while having other check-ups at a healthcare facility. </span><b>DM/MC</b>\r\n\r\n<i><span style=\"font-weight: 400;\">This story was produced by the</span></i><a href=\"http://bhekisisa.org./\"> <span style=\"font-weight: 400;\">Bhekisisa Centre for Health Journalism</span></a><i><span style=\"font-weight: 400;\">. Sign up for the</span></i><a href=\"http://bit.ly/BhekisisaSubscribe\"> <i><span style=\"font-weight: 400;\">newsletter</span></i></a><i><span style=\"font-weight: 400;\">.</span></i>\r\n\r\n<img loading=\"lazy\" src=\"https://syndicate.app/st.php\" />\r\n<script async=\"true\" src=\"https://syndicate.app/st.js\" type=\"text/javascript\"></script>",
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"description": "<span style=\"font-weight: 400;\">Free home tests for four common – and curable – sexually transmitted infections (STIs) – </span><a href=\"https://www.mayoclinic.org/diseases-conditions/gonorrhea/symptoms-causes/syc-20351774\"><span style=\"font-weight: 400;\">gonorrhoea</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.mayoclinic.org/diseases-conditions/chlamydia/symptoms-causes/syc-20355349\"><span style=\"font-weight: 400;\">chlamydia</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.mayoclinic.org/diseases-conditions/syphilis/symptoms-causes/syc-20351756#:~:text=Syphilis%20is%20a%20bacterial%20infection,membrane%20contact%20with%20these%20sores.\"><span style=\"font-weight: 400;\">syphilis</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://www.mayoclinic.org/diseases-conditions/trichomoniasis/symptoms-causes/syc-20378609#:~:text=Trichomoniasis%20is%20a%20common%20sexually,trichomoniasis%20typically%20have%20no%20symptoms.\"><span style=\"font-weight: 400;\">trichomoniasis</span></a><span style=\"font-weight: 400;\"> – could soon be available at </span><a href=\"https://getcheckedgocollect.org.za/ccmdd/\"><span style=\"font-weight: 400;\">chronic medicine pick-up points</span></a><span style=\"font-weight: 400;\"> around the country, according to a draft of South Africa’s fifth </span><a href=\"https://nsp.sanac.org.za/uploads/files/NSPn-for-HIV-TB-STIs-2023-2028-Draft3C.pdf\"><span style=\"font-weight: 400;\">HIV, TB and STI action plan</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">Government clinics will also roll out STI tests that give results on the same day. </span>\r\n\r\n<span style=\"font-weight: 400;\">The new plan is being finalised after comments from the public and civil society were added, says Nelson Dlamini, communications manager at the South African National Aids Council. The final draft will be published on </span><a href=\"https://www.who.int/campaigns/world-tb-day\"><span style=\"font-weight: 400;\">World TB Day</span></a><span style=\"font-weight: 400;\"> on 24 March.</span>\r\n\r\n<span style=\"font-weight: 400;\">The updated strategy will run from 2023 to 2028. </span>\r\n\r\n<span style=\"font-weight: 400;\">Until now, South Africa’s public health sector hasn’t used tests as a standard to diagnose these four STIs (apart from </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">syphilis</span></a><span style=\"font-weight: 400;\">). Instead, people get treated only if they show up to a facility with symptoms such as </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">genital sores</span></a><span style=\"font-weight: 400;\"> or </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">discharge</span></a><span style=\"font-weight: 400;\"> coming from their penis or vagina. </span>\r\n\r\n<span style=\"font-weight: 400;\">This is called “</span><a href=\"https://sahivsoc.org/Files/SAHCS%202022%20STI%20guidelines.pdf\"><span style=\"font-weight: 400;\">syndromic management</span></a><span style=\"font-weight: 400;\">” and it’s used by </span><a href=\"https://www.who.int/publications/i/item/9789240024168\"><span style=\"font-weight: 400;\">many low- and middle-income countries</span></a><span style=\"font-weight: 400;\">, including </span><a href=\"https://www.jica.go.jp/project/tanzania/001/materials/pdf/sti_01.pdf\"><span style=\"font-weight: 400;\">Tanzania</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05276-0\"><span style=\"font-weight: 400;\">Mozambique</span></a><span style=\"font-weight: 400;\">. The </span><a href=\"https://sahivsoc.org/Files/SAHCS%202022%20STI%20guidelines.pdf\"><span style=\"font-weight: 400;\">logic</span></a><span style=\"font-weight: 400;\"> is that many facilities don’t have easy access to a laboratory, so it might take up to </span><a href=\"https://www.sciencedirect.com/science/article/pii/S0732889316303467\"><span style=\"font-weight: 400;\">four days</span></a><span style=\"font-weight: 400;\"> for people to get their results, and then they might not return to the clinic to get the news or the medicine anyway. </span>\r\n\r\n<span style=\"font-weight: 400;\">In South Africa’s private sector, however, using lab tests to diagnose STIs is commonplace. </span>\r\n\r\n<span style=\"font-weight: 400;\">The trouble with the syndromic method is twofold: </span>\r\n\r\n<span style=\"font-weight: 400;\">First, </span><a href=\"https://www.sciencedirect.com/science/article/pii/S0091743502000580\"><span style=\"font-weight: 400;\">most people</span></a><span style=\"font-weight: 400;\"> with these STIs are asymptomatic, meaning they don’t show any symptoms (that was the case for more than three-quarters of women in </span><a href=\"https://academic.oup.com/jid/article/206/1/6/833481\"><span style=\"font-weight: 400;\">one local study</span></a><span style=\"font-weight: 400;\">). So, with the current approach in the public health system, it means they won’t be treated and will continue to spread the infection to others.</span>\r\n\r\n<span style=\"font-weight: 400;\">What’s more, the Health Department doesn’t consistently collect data on how many people have one of the four common STIs (gonorrhoea, chlamydia, syphilis and trichomoniasis) on a national level. Instead, the department and the National Institute for Communicable Diseases </span><a href=\"https://www.nicd.ac.za/wp-content/uploads/2017/03/3Final-25-April-2017_Revised-NAS_v5_NICD.pdf\"><span style=\"font-weight: 400;\">run data collection drives every now and again</span></a><span style=\"font-weight: 400;\">, where samples are collected from people (who are showing symptoms) in all nine provinces and sent to the lab. The results are used to make predictions about how many of these infections are going around, and the department then decides whether it’s buying the correct medicines. </span>\r\n\r\n<i><span style=\"font-weight: 400;\">Read in </span></i><span style=\"font-weight: 400;\">Daily Maverick:</span><i><span style=\"font-weight: 400;\"> “</span></i><a href=\"https://www.dailymaverick.co.za/article/2022-08-11-one-pill-within-three-days-of-condomless-sex-could-stop-three-sexually-transmitted-infections/\"><i><span style=\"font-weight: 400;\">One pill within three days of condomless sex could stop three sexually transmitted infections</span></i></a><i><span style=\"font-weight: 400;\">”</span></i>\r\n\r\n<span style=\"font-weight: 400;\">This type of data collection makes it difficult to know whether the country reached the government’s </span><a href=\"https://bhekisisa.org/wp-content/uploads/2023/02/NSP-MTR-Full-Report-2017-2022-FINAL.pdf\"><span style=\"font-weight: 400;\">previous HIV and STI plan’s</span></a><span style=\"font-weight: 400;\"> (2017-22) goal to find </span><a href=\"https://bhekisisa.org/wp-content/uploads/2023/02/NSP-MTR-Full-Report-2017-2022-FINAL.pdf\"><span style=\"font-weight: 400;\">50%</span></a><span style=\"font-weight: 400;\"> more symptomless cases of these four infections by the end of 2022, says Yogan Pillay, who heads the </span><a href=\"https://www.clintonhealthaccess.org/south-africa/\"><span style=\"font-weight: 400;\">local arm of the Clinton Health Access Initiative</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">When gonorrhoea, syphilis or chlamydia aren’t treated, they can </span><a href=\"https://www.tandfonline.com/doi/pdf/10.1016/S0968-8080(12)40653-X\"><span style=\"font-weight: 400;\">cause infertility</span></a><span style=\"font-weight: 400;\">, increase the chance of </span><a href=\"https://www.who.int/news-room/fact-sheets/detail/sexually-transmitted-infections-(stis)\"><span style=\"font-weight: 400;\">contracting HIV</span></a><span style=\"font-weight: 400;\"> or lead to </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525108/\"><span style=\"font-weight: 400;\">stillbirth</span></a><span style=\"font-weight: 400;\">. People with HIV who aren’t on antiretroviral treatment can also </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715951/\"><span style=\"font-weight: 400;\">spread the virus easier</span></a><span style=\"font-weight: 400;\"> when they have gonorrhoea.</span><span style=\"font-weight: 400;\"> </span>\r\n\r\n<span style=\"font-weight: 400;\">The second problem is that people who do have symptoms (and who show up to a clinic for help) will get an antibiotic that works against more than one infection, because health workers don’t know exactly what they’re treating. This could result in some bugs becoming resistant to those medicines, </span><a href=\"https://bhekisisa.org/article/2022-07-22-superbugs-could-cost-you-an-arm-or-a-leg-why-hospitals-need-more-money-to-fight-drug-resistance/\"><span style=\"font-weight: 400;\">something South Africa already struggles with</span></a><i><span style=\"font-weight: 400;\">.</span></i>\r\n\r\n<span style=\"font-weight: 400;\">In short: the public health system is potentially overtreating people with symptoms and undertreating those without, explains Johan Hugo, a senior clinical adviser at the </span><a href=\"https://www.anovahealth.co.za\"><span style=\"font-weight: 400;\">Anova Health Institute</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">But the way South Africa approaches both these problems – through diagnostics and data – is changing. Here’s how. </span>\r\n<h4>Diagnostics: finding the patients</h4>\r\n<span style=\"font-weight: 400;\">Testing people, such as pregnant women, when they come to clinics could make a big difference, according to </span><a href=\"https://www.hindawi.com/journals/idog/2018/3946862/\"><span style=\"font-weight: 400;\">research</span></a><span style=\"font-weight: 400;\"> published in the journal </span><i><span style=\"font-weight: 400;\">Infectious Diseases in Obstetrics and Gynaecology </span></i><span style=\"font-weight: 400;\">in 2018</span><i><span style=\"font-weight: 400;\">. </span></i>\r\n\r\n<span style=\"font-weight: 400;\">At three clinics in Tshwane, pregnant women used rapid tests for gonorrhoea, chlamydia and trichomoniasis. Nine out of 10 of those who tested positive for any of these infections could start treatment immediately, without having to wait longer for help than they would have been in the queue.</span>\r\n\r\n<span style=\"font-weight: 400;\">However, these tests are </span><a href=\"https://journals.co.za/doi/10.36303/SAGP.2022.3.3.0132\"><span style=\"font-weight: 400;\">not widely available</span></a><span style=\"font-weight: 400;\"> in South Africa’s public sector. State facilities have rapid tests for syphilis, which are </span><a href=\"https://www.health.gov.za/wp-content/uploads/2020/11/sti-guidelines-27-08-19.pdf\"><span style=\"font-weight: 400;\">commonly given to pregnant women and survivors of sexual violence</span></a><span style=\"font-weight: 400;\">, but are not available as a standard or for the three other STIs. </span>\r\n\r\n<span style=\"font-weight: 400;\">Under the new STI plan, though, tests would be available to many more people, including all teenage girls and young women (between 15 and 24 years old), </span><a href=\"https://www.cdc.gov/hiv/group/sexworkers.html\"><span style=\"font-weight: 400;\">sex workers</span></a><span style=\"font-weight: 400;\">, </span><a href=\"https://www.cdc.gov/std/treatment-guidelines/trans.htm\"><span style=\"font-weight: 400;\">transgender people</span></a><span style=\"font-weight: 400;\">, men who have sex with men and survivors of gender-based violence. </span>\r\n\r\n<span style=\"font-weight: 400;\">In the private sector, </span><a href=\"https://famka.co.za/product-category/test-kit/\"><span style=\"font-weight: 400;\">rapid self-test kits for single STIs cost between R125 and R200 </span></a><span style=\"font-weight: 400;\">or </span><a href=\"https://famka.co.za/product/std-combo-kit/\"><span style=\"font-weight: 400;\">R500</span></a><span style=\"font-weight: 400;\"> for a kit that will screen for all four curable STIs.</span>\r\n\r\n<span style=\"font-weight: 400;\">Another option for the state could be to use the GeneXpert machines, already available for testing for TB, to pick up whether someone has a chlamydia and gonorrhoea infection, says Hugo. </span>\r\n\r\n<span style=\"font-weight: 400;\">With this machine, test results are available within </span><a href=\"https://www.frontiersin.org/articles/10.3389/fcimb.2021.784610/full#:~:text=On%20the%20other%20hand%2C%20the,amplification%20in%20approximately%2090%20min.\"><span style=\"font-weight: 400;\">90 minutes</span></a><span style=\"font-weight: 400;\"> when using the chlamydia and gonorrhoea cartridges. All health workers have to do is replace the TB or HIV test kit inside the machine with one that works for a specific STI. </span>\r\n\r\n<span style=\"font-weight: 400;\">When </span><a href=\"https://sti.bmj.com/content/sextrans/early/2018/05/10/sextrans-2017-053443.full.pdf\"><span style=\"font-weight: 400;\">researchers tested this method</span></a><span style=\"font-weight: 400;\"> in 12 clinics in Australia, it worked just as well as laboratory tests, </span><a href=\"https://sti.bmj.com/content/sextrans/early/2018/05/10/sextrans-2017-053443.full.pdf\"><span style=\"font-weight: 400;\">research shows</span></a><span style=\"font-weight: 400;\"> — and it’s much faster.</span>\r\n\r\n<span style=\"font-weight: 400;\">A </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918163/\"><span style=\"font-weight: 400;\">study</span></a><span style=\"font-weight: 400;\"> from Durban that used the GeneXpert machine to test for STIs gave similar results, and women who tested positive received medication and a pack of information, condoms and treatment for their sexual partners as soon as the results were out. The patients told researchers that this method worked for them because they got results quickly (within about two hours) and because they could help their partners.</span>\r\n\r\n<i><span style=\"font-weight: 400;\">Read in </span></i><span style=\"font-weight: 400;\">Daily Maverick:</span><i><span style=\"font-weight: 400;\"> “</span></i><a href=\"https://www.dailymaverick.co.za/article/2023-02-13-conversations-about-sex-we-must-do-better-for-young-people/\"><i><span style=\"font-weight: 400;\">Conversations about sex – we must do better for young people</span></i></a><i><span style=\"font-weight: 400;\">”</span></i>\r\n\r\n<span style=\"font-weight: 400;\">The cartridges are pricey, though – it could cost </span><a href=\"https://sti.bmj.com/content/sextrans/93/Suppl_2/A211.1.full.pdf\"><span style=\"font-weight: 400;\">about R250</span></a><span style=\"font-weight: 400;\"> a shot to test for gonorrhoea. So, although the Durban study showed that this method could be good for diagnosing STIs fast, it didn’t look at whether it would be an affordable option for South Africa. </span>\r\n\r\n<span style=\"font-weight: 400;\">But if people can get their STI results so fast in clinics, why would the government also roll out home tests?</span>\r\n\r\n<hr />\r\n\r\n<strong>Visit <a href=\"https://www.dailymaverick.co.za?utm_source=direct&utm_medium=in_article_link&utm_campaign=homepage\"><em>Daily Maverick's</em> home page</a> for more news, analysis and investigations</strong>\r\n\r\n<hr />\r\n\r\n<span style=\"font-weight: 400;\">It’s a way to get around stigma, the action plan says. Discrimination at clinics makes it hard for people to get the health services they need – especially people who are at a high risk of contracting STIs, such as </span><a href=\"https://www.cdc.gov/hiv/group/sexworkers.html\"><span style=\"font-weight: 400;\">sex workers</span></a><span style=\"font-weight: 400;\"> and </span><a href=\"https://www.cdc.gov/std/treatment-guidelines/trans.htm\"><span style=\"font-weight: 400;\">transgender people</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">Close to 40% of the practitioners involved in </span><a href=\"https://sti.bmj.com/content/84/2/150.short\"><span style=\"font-weight: 400;\">one study</span></a><span style=\"font-weight: 400;\"> felt uncomfortable caring for patients who come from such high-risk groups, also called key populations.</span>\r\n\r\n<span style=\"font-weight: 400;\">In a Brazilian study, transgender women said they were far </span><a href=\"https://www.sciencedirect.com/science/article/pii/S1413867022000447\"><span style=\"font-weight: 400;\">more comfortable collecting their own samples</span></a><span style=\"font-weight: 400;\"> (from their anus, urethra or mouth) than having a health worker do it. </span>\r\n\r\n[caption id=\"attachment_1565054\" align=\"alignnone\" width=\"720\"]<img class=\"size-full wp-image-1565054\" src=\"https://www.dailymaverick.co.za/wp-content/uploads/2023/02/MC-STI-2-1.jpg\" alt=\"\" width=\"720\" height=\"360\" /> A rapid screening test for syphilis. (Photo: iStock)[/caption]\r\n\r\n<span style=\"font-weight: 400;\">Pillay cautions, though, that sending out self-test kits could create another set of problems when it comes to keeping track of infections. </span>\r\n\r\n<span style=\"font-weight: 400;\">Health workers wouldn’t know whether people used the test, he says, and if they have, there’s no guarantee they would come in for treatment. </span>\r\n<h4>Data: Getting the numbers</h4>\r\n<span style=\"font-weight: 400;\">There were more than 4.5 million estimated new cases of gonorrhoea in South Africa in 2017, as well as 5.8 million new chlamydia infections and 70,000 cases of syphilis, </span><a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188893/\"><span style=\"font-weight: 400;\">according to a 2018 modelling study</span></a><span style=\"font-weight: 400;\">. </span>\r\n\r\n<span style=\"font-weight: 400;\">But these figures are only educated guesses and could be inflated, the researchers caution, because there wasn’t much data for them to work with. That meant they had to do “crude” calculations based on figures from a bunch of smaller studies, which didn’t all have the same research method. </span>\r\n\r\n<span style=\"font-weight: 400;\">Under the new HIV and STI plan, the Health Department says it will conduct nationally representative studies to determine how many of these STIs are going around among the people most likely to be infected (such as sex workers and young women). </span>\r\n\r\n<span style=\"font-weight: 400;\">This data will make it easier for South Africa to find and treat more people with STIs, without having to test everyone in the country, Pillay says. </span>\r\n\r\n<span style=\"font-weight: 400;\">In the meantime, health facilities are going to change the way they collect data for people who are showing symptoms of STIs. </span>\r\n\r\n<span style=\"font-weight: 400;\">At the moment, health workers only record information for </span><a href=\"https://emedicine.medscape.com/article/778374-overview\"><span style=\"font-weight: 400;\">male urethritis syndrome</span></a><span style=\"font-weight: 400;\">. This is a condition where a bacterial infection – which is sexually transmitted – causes inflammation in the urethra (the tube along which urine flows out from the bladder). Close to </span><a href=\"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205863#pone.0205863.s002\"><span style=\"font-weight: 400;\">311,000 men showed up at healthcare facilities with symptoms of this condition</span></a><span style=\"font-weight: 400;\"> in 2017. </span>\r\n\r\n<span style=\"font-weight: 400;\">While </span><a href=\"https://www.cdc.gov/std/health-disparities/stds-women-042011.pdf\"><span style=\"font-weight: 400;\">men are more likely than women to show symptoms</span></a><span style=\"font-weight: 400;\"> of infections such as chlamydia and gonorrhoea, they’re much less likely to ask for help quickly, Pillay notes. </span>\r\n\r\n<span style=\"font-weight: 400;\">But in the next few months, health workers are likely to start recording cases of </span><a href=\"https://www.ampath.co.za/storage/347/ampathchat_66-vaginal-discharge-syndrome-17022020-final.pdf\"><span style=\"font-weight: 400;\">vaginal discharge syndrome</span></a><span style=\"font-weight: 400;\"> in women and </span><a href=\"https://clinicalinfo.hiv.gov/en/glossary/genital-ulcer-disease\"><span style=\"font-weight: 400;\">genital ulcer disease</span></a><span style=\"font-weight: 400;\"> too, he says, because these are underlying symptoms of STIs like chlamydia and </span><a href=\"https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus\"><span style=\"font-weight: 400;\">herpes</span></a><span style=\"font-weight: 400;\"> among this gender. </span>\r\n\r\n<span style=\"font-weight: 400;\">Tracking these two syndromes can help the government to understand STI trends in women who show symptoms, so that it can pick up in which areas more intensive testing and treatment has to happen, explains Pillay.</span>\r\n\r\n<span style=\"font-weight: 400;\">To help make sure the people who need treatment get it, the department also plans to add an STI section to the country’s tracking platform, </span><a href=\"https://www.tier.net/\"><span style=\"font-weight: 400;\">Tier.Net</span></a><span style=\"font-weight: 400;\">, that helps monitor people who are on HIV and TB treatment. </span>\r\n\r\n<span style=\"font-weight: 400;\">This system keeps track of people who are on HIV medication, for example, so that health workers know to test their viral load (how much of the virus is in their blood) each time the patient arrives for a check-up at the clinic. The online platform doubles as a way to</span><a href=\"https://sahivsoc.org/Files/transition.pdf\"><span style=\"font-weight: 400;\"> collect data and filter it to the government</span></a><span style=\"font-weight: 400;\"> to help manage the country’s response to HIV infections. In the same way it could help to also keep track of STI numbers. </span>\r\n\r\n<span style=\"font-weight: 400;\">But Tier.Net has had drawbacks, research shows. Health workers have battled to keep it updated alongside the paper records, which has </span><a href=\"https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000312\"><span style=\"font-weight: 400;\">resulted in mismatches</span></a><span style=\"font-weight: 400;\"> between what’s on electronic sheets and what’s in a clinic’s books.</span>\r\n\r\n<span style=\"font-weight: 400;\">Until then, Pillay says, health workers should simply encourage more people to get screened for STIs while having other check-ups at a healthcare facility. </span><b>DM/MC</b>\r\n\r\n<i><span style=\"font-weight: 400;\">This story was produced by the</span></i><a href=\"http://bhekisisa.org./\"> <span style=\"font-weight: 400;\">Bhekisisa Centre for Health Journalism</span></a><i><span style=\"font-weight: 400;\">. Sign up for the</span></i><a href=\"http://bit.ly/BhekisisaSubscribe\"> <i><span style=\"font-weight: 400;\">newsletter</span></i></a><i><span style=\"font-weight: 400;\">.</span></i>\r\n\r\n<img src=\"https://syndicate.app/st.php\" />\r\n<script async=\"true\" src=\"https://syndicate.app/st.js\" type=\"text/javascript\"></script>",
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