"[He] departed on the 1st July 2018 from complications of systematic lupus erythematosus, simply known as lupus," said family spokesperson Linda Makatini in a statement.
Lupus disease causes chronic inflammation as an autoimmune response to the body's own cells.
Health24: Lupus
The family said it would gather at home in Forest Town on Wednesday night for prayers to remember Vusi Zuma - who was the youngest son of Zuma and his late wife Kate Mantsho.
READ: So who are Zuma's 23 children?
A memorial service would be held on Thursday. This will only be open to close friends and family. DM
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South Africa
Zuma's son died of lupus - family spokesperson
Former president Jacob Zuma's son, Vusi Nhlakanipho Zuma, died as a result of lupus, a family representative said on Wednesday.